Relative leukocyte telomere length and the risk of lung cancer progression in individuals with pulmonary nodules.

Although the improvements in AUC and IDI were modest and did not reach statistical significance in most models (ΔAUC: 0.003–0.019, all P > 0.05; IDI: 0.003–0.008, all P > 0.05, except for model 2), the NRI values were consistently significant across all five models (NRI: 0.380–0.847; all P < 0.05) (Table 3 ).

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In addition, the associations of rLTL with nodule diameter (per 1-mm increase; β = 0.014 ± 0.008, P = 0.081) and irregular shape (presence vs absence; β = 0.238 ± 0.136, P = 0.081) were borderline significant after adjustment.

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