Barely Significant
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Targeted Epigenetic Activation of <i>CTLA4</i> in Haploinsufficiency Cellular Models by CRISPRa.

Biomedicines · 2026 · PMC13113370 · PMID 42072337

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did not reach statistical significanceno p-value reported
Whilst the mean CTLA4 expression in HEK293T CTLA4 +/+ cells appeared slightly higher than in HEK293T CTLA4 +/− , the difference did not reach statistical significance, confirming that a single functional allele is sufficient to support strong CRISPRa-induced CTLA4 transcription.

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