Like LAL, the activity of cathepsins B and L showed a clear trend towards significant decreases in LKO mice of both sexes ( Figure 5 c–f), indicating impaired lysosomal lipid degradation and protein turnover in these mice compared to the floxed mice. 3.4.
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Hepatocyte-Specific Deletion of Betaine-Homocysteine Methyltransferase Disrupts Methionine Metabolism and Promotes the Spontaneous Development of Hepatic Steatosis.
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