Dosimetric Comparison of Automated Noncoplanar VMAT (HyperArc) Versus CyberKnife for Single-Fraction Vestibular Schwannoma Stereotactic Radiosurgery.

The V 12Gy distributions in Figure 6 demonstrate that most cases clustered near small volumes, with occasional higher outliers that reflect patient-specific anatomy rather than a consistent technique-driven effect; there was a trend toward lower V 12Gy with HA-HDMLC compared with HA-SMLC, but it did not reach statistical significance ( p = 0.063).

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Second, multiple pairwise comparisons were performed across several correlated dosimetric endpoints without formal multiplicity adjustment, so an increased risk of type I error cannot be excluded, particularly for borderline significant findings.

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