Epigenetics as Biomarkers of Cumulative Physical Performance in Community-Dwelling Adults: A Cross-Sectional Feasibility Study.

Although this association did not reach statistical significance, it suggests a possible trend within a relatively narrow range of methylation values, whereby higher methylation levels may be associated with reduced physical performance.

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While the youngest (1st tertile) and oldest (3rd tertile) subgroups showed virtually no correlation between age and performance (ρ = −0.04, p = 0.89 and ρ = −0.23, p = 0.66), the middle (2nd) tertile demonstrated a moderate negative correlation (ρ = −0.52, p = 0.29), although it did not reach statistical significance.

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