CHRNB4-Mediated Neuroactive Signaling Rewiring Drives Adaptive Resistance to BCL-2 Inhibition in Acute Myeloid Leukemia.

Cancers (Basel) · 2026 · PMC13115082 · PMID 42073514

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While VEN treatment significantly reduced, or showed a trend toward reducing, the colony number and size of PAR cells, both the VENM and VENK cells showed minimal changes in colony number and size, indicating reduced sensitivity ( Figure 1 E,F).

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