Molecular Links Between Smoking, COPD, and Lung Cancer: A DNA Methylation Perspective.

Cancers (Basel) · 2026 · PMC13115189 · PMID 42073597

Europe PMC DOI

hedged sentences

0.0000

closest p · 0.0× alpha

0.2400

boldest claim

The sentences

highly significantp < 2 × 10 −16actually significant

AHRR also showed highly significant hypomethylation ( p < 2 × 10 −16 ) ( Figure 4 I), confirming its consistent pattern of methylation loss across both lung cancer subtypes.

also in 132,142 other papers

did not reach statistical significancep = 0.24not close (p > 0.1)

Unlike in LUAD, CDH13 did not reach statistical significance in LUSC ( p = 0.24) ( Figure 4 B), suggesting a subtype-specific methylation pattern for this gene.

also in 111,027 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.