Ferroptosis-Based Nanotherapeutic Strategies to Overcome Temozolomide Resistance in Glioblastoma: A Systematic Review and Meta-Analysis.

Curr Oncol · 2026 · PMC13115328 · PMID 42041713

Europe PMC DOI

hedged sentence

0.0800

closest p · 1.6× alpha

0.0800

boldest claim

The sentences

did not reach statistical significancep = 0.08so close (0.05 < p ≤ 0.1)

The subgroup analysis as shown in Figure 3 that nanoparticle-mediated delivery systems achieved a higher magnitude of sensitization (pooled SMD: −8.62) than small-molecule interventions (pooled SMD: −5.58), although this difference did not reach statistical significance ( p = 0.08).

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