Single-Cell Analysis Highlights Pivotal Role of Eosinophil-Basophil Mast Cell Progenitor-Related Mechanism in Primary Immune Thrombocytopenia.

Although the correlation analysis revealed a positive trend between CXCL8 expression and EBMP cell proportion in ITP patients, this association did not reach statistical significance ( Figure 5 G, p > 0.05).

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We have identified precursors of various immune cells and found a decreasing trend of pre-B cells in the bone marrow of ITP patients, consistent with previous reports of a reduction in total B cells in ITP bone marrow [ 18 ].

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