Synphilin-1 Is Essential for Cytoskeletal Integrity of Brain Ventricular Cilia and Mitochondrial Proteostasis.

Int J Mol Sci · 2026 · PMC13116186 · PMID 42074141

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did not reach statistical significanceno p-value reported

Although Sph-1 KO mice remained on the accelerating rod for slightly longer periods than NonTg controls, this difference did not reach statistical significance ( Figure 5 C).

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a mild trendno p-value reported

However, older Sph-1 KO mice showed a mild trend toward dopaminergic degeneration ( Figure 7 ), consistent with the relatively high synphilin-1 expression in the substantia nigra.

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