Intraoperative Magnesium Sulfate and Early Postoperative Analgesia in Lumbar Microdiscectomy: A Retrospective Clinical Study Integrating Molecular Docking and Protein Interaction Network Analysis.

For a random protein set of comparable size, the expected number of edges was 8, whereas the observed network contained 44 interactions, resulting in a highly significant PPI enrichment p -value < 1.0 × 10 −16 .

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Nevertheless, modest trends toward lower postoperative NRS scores and reduced intraoperative opioid requirements were observed in the MgSO 4 group; however, these differences did not reach statistical significance and should be interpreted cautiously.

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