Protein-Encoding Chemically Modified mRNAs for Musculoskeletal Tissue Regeneration and Repair.

J Funct Biomater · 2026 · PMC13117233 · PMID 42042273

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did not reach statistical significanceno p-value reported

Intra-articular injection of Runx1 mRNA (1 μg in 20 μL volume every 3 days for one month) via PAsp(DET) nanomicelles improved MCL- and MM-transection-induced OA, but the effects did not reach statistical significance compared to GFP mRNA.

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