A strong, albeit borderline significant, trend was also observed for progressive disease after neoadjuvant chemotherapy, suggesting that chemoresistance is a major clinical hurdle [ 17 ].
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Imaging and Clinicopathological Features of Squamous Cell Metaplastic Breast Carcinoma: A 22-Case Retrospective Study.
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Regarding marker expression, while CK5/6 and p63 positivity confirmed squamous differentiation, EGFR positivity (59.1%) was associated with a trend toward poorer prognosis, though this did not reach statistical significance.