Neuromodulatory Effects of Substantia Nigra Pars Reticulata Deep Brain Stimulation (SNr-DBS) in the 6-Hydroxydopamine Rat Model of Parkinson's Disease.

Medicina (Kaunas) · 2026 · PMC13117652 · PMID 42075586

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did not reach statistical significanceno p-value reported

Despite these improvements in the SNr-DBS group compared to the sham group, direct comparisons between the two groups did not reach statistical significance.

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a positive trendno p-value reported

Discussion The most important finding of this study is that 14-day SNr-DBS markedly enhanced locomotor activity in a 6-OHDA-induced PD model and showed a positive trend toward improving balance and motor coordination.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.