Marine-Derived Chitooligosaccharide Attenuates Obesity and Metabolic Syndrome in Bama Pigs Through LXR-Mediated Cholesterol Metabolism and Gut Microbiota Modulation.

Consistently, the intervention of COST exhibited a restorative trend, moderately upregulating the mRNA expression of ZO-1, Claudin-1 and Occludin, although the differences did not reach statistical significance when compared to the Model group ( Figure 5 B).

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This structural restoration was accompanied by a highly significant reduction in serum LPS levels and a restorative trend in the mRNA expression of intestinal tight junction proteins (ZO-1, Claudin-1, and Occludin).

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