Lingguizhugan Decoction Ameliorates MASLD by Modulating the Gut Microbiota and Enriching Non-12-OH Bile Acids to Activate TGR5-Mediated Thermogenesis.

Concurrently, LGZG alleviated hepatic injury, as evidenced by reduced serum ALT levels and a decreasing trend in AST levels, lower hepatic lipid accumulation, and improved histopathological scores ( Figure 1 C and Figure 2 A–D).

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Following LGZG treatment, although the total BA pool size remained relatively stable and did not reach statistical significance compared to the HFD group, the intervention significantly remodeled the overall BA compositional profile, shifting it toward a state resembling the control group ( Figure 4 A,B).

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