Baseline RDW combined with dynamic trajectory: Predictive value for 30-day all-cause mortality in patients with sepsis-induced coagulopathy and development of a nomogram.

The results of subgroup analysis are shown in S3 Fig in S1 File : in subgroups such as mechanical ventilation, continuous renal replacement therapy, hypertension, diabetes, vasopressors, INR, and fresh frozen plasma, the mortality risk of the rapidly ascending RDW group (Traj1) was significantly higher than that of the stable low-level group (Traj0) ( P < 0.05); while in subgroups such as age, chronic kidney disease, and Hb, although the mortality risk of the Traj1 group showed an increasing trend, the difference in some subgroups did not reach statistical significance ( P > 0.05), which may be related to the limited statistical power of smaller subgroups and residual confounding.

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Taking the low baseline RDW group as the reference, in Model 1, the mortality risk of the Q2 group (HR = 2.478, 95% CI: 1.697–3.619, P < 0.001) and Q3 group (HR = 5.595, 95% CI: 3.949–7.927, P < 0.001) was significantly increased; in Model 2, the HR of the two groups was 2.254 (95% CI: 1.539–3.300, P < 0.001) and 5.032 (95% CI: 3.537–7.159, P < 0.001) respectively; in Model 3, the association of the Q2 group was weakened to marginally significant (HR = 1.442, 95% CI: 0.981–2.121, P = 0.063), while the Q3 group still significantly increased the mortality risk (HR = 2.666, 95% CI: 1.854–3.834, P < 0.001).

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