CD8 + T cells co-cultured with AICL-expressing CD4 + T cells showed a trend toward increased frequencies of total TNF + and/or IFN-γ + cells compared with CD8 + T cells cultured alone (Fig. 3E ).
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The AICL-KLRF1 axis supports CD4-CD8 T cell communication and cytokine competence in pre-exhausted CD8<sup>+</sup> T cells.
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