Comprehensive genome sequencing associates elevated mitochondrial DNA and homoplasmy with early stage I of pancreatic cancer.

iScience · 2026 · PMC13122664 · PMID 42058907

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an interesting trendno p-value reported

Here, we report an interesting trend for high mtDNA coverage, homoplasmy, and associated mutations in PDAC patients’ cell-free DNA (cfDNA).

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did not reach statistical significanceno p-value reported

Conversely, heteroplasmy, while trending slightly higher in the PDAC patients' cfDNA, but lower relative to homoplasmy, did not reach statistical significance ( Figure 4 B).

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