highly significantp = 6 × 10− 55
The modest but highly significant K9me2 gene body correlation with expression (Spearman ρ = −0.114, p = 6 × 10− 55 ) confirms functional relevance at individual loci. 4.2.
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Nitric oxide generates a coordinated histone modification signature consistent with chromatin compaction, linked to methyl-modifying enzyme dysregulation and tumor-permissive gene silencing.
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nominally significantp < 0.05
Of 912 total comparisons, 207 were nominally significant (p < 0.05), 74 survived per-family FDR at q < 0.05, and 147 at q < 0.10. 2.4.