Consistently, the immumohistochemical staining data revealed that the Ki-67, OTUB2, EIF4A3, and TPI1 proteins were decreased in tumor tissues of the sh-OTUB2 group relative to the sh-NC group, and the oe-OTUB2 group showed an adverse trend (Fig. 8 E).
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Deubiquitination and stabilization of EIF4A3 by OTUB2 contributes to TPI1-mediated glycolysis and TNBC progression.
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