“an adverse trend”

We observed an adverse trend effect among males ( p = 0.056) and a protective trend effect among females ( p = 0.073) in the verbal memory domain, although these observations did not reach statistical significance.

When additionally adjusting for the first-year rejection burden (0/1/≥2 antirejection treatment cycles), the CIT effect attenuated, and the rejection burden showed an adverse trend: ≥2 vs. 0: adjusted HR 8.29 (95% CI 0.93–74.01, p = 0.058); 1 vs. 0: adjusted HR 5.29 (95% CI 0.49–57.62, p = 0.172); CIT per 60 min: adjusted HR 1.07 (95% CI 0.98–1.17, p = 0.122; events n = 11; analysis set n = 24).

The development of grade I–II acute GVHD tended to lower the risk of NRM compared with no acute GVHD in PTCy (HR = 0.16, 95% CI = 0.02–1.36, P = 0.093) and CBT (HR = 0.55, 95% CI = 0.27–1.11, P = 0.093), whereas there was an adverse trend in MDT (HR = 1.95, 95% CI = 0.97–3.91, P = 0.059) ( Supplementary Table 6 ).

Globally, age-standardized mortality rates for diabetes show an adverse trend, increasing by 3% from 2000 to 2019 [ 1 ].

In the current study, a positive correlation with the EMT markers was evident for BMP2 and BMP6, while an adverse trend was evident for GDF9 and GDF15.

They found that the use of aligners for 12 hours or more creates an adverse trend for an acid-induced demineralization environment due to the abundance of Streptococcus and Lactobacillus sp.

The best results were obtained when using PR at 9 g/kg in the diet, while higher levels (12 g/kg PR) showed an adverse trend in the evaluated parameters.

reported an adverse trend in HDL-C levels among Iranian patients with diabetes [ 37 ].

In contrast, the high-risk group exhibited an adverse trend in these aspects.

33 Such an adverse trend appeared consistent, despite developments in 2000-2010, 34 as well as the past decade, with studies reporting a 1-year TVF rate of 19% 15 , and 5-year rates of mortality, MI, or TVR of up to 56.1% in 173 patients. 17 This phenomenon likely is driven by the fact that patients undergoing PCI post-CABG tend to be older and to carry more comorbidities, predisposing them to higher event rates that cannot be mitigated further by the contemporary armamentaria in cardiovascular care.

TP exhibited an adverse trend.

investigating 8.986 OSCC patients from the Taiwanese national database, PORT/POCRT initiation time beyond 7 weeks only was associated with an adverse trend in survival ( 24 ).

Brain function is vulnerable to the consequences of inadequate sleep, an adverse trend that is increasingly prevalent.

CD16/32 expression was obviously increased in the SE group at 24 and 72 hours post-SE compared to the SE+MCC950 group ( Figure 2A–E ), whereas CD206 expression exhibited an adverse trend, being dramatically decreased in the SE group at 24 hours ( Figure 2A, B and G–I ).

The relative expression of CsGA2ox1 showed an adverse trend with the content of GA 20 and GA 3 .

There was an adverse trend between the soluble and storage carbohydrates levels with an increase in light intensity or decrease in lighting duration in basil leaves (Fig. 4 C).

This suggests an adverse trend associated with these therapies.

This shows an adverse trend compared to MLR and requires further investigation.

By contrast, the levels of Ca and K in grains had an adverse trend to those of the soil (Figure 1a ; Figure S1c,d , Supporting Information).

In China, the period effects showed improvement during 2002–2006, while the rest of the past two decades exhibited an adverse trend.

DOC showed an adverse trend to SOM, with the DOC content increasing from 2.91 g/kg to 4.68 g/kg between the rice TIL and JOI stages and then decreasing to 4.04 g/kg from the JOI to MAT stages, primarily due to the comprehensive utilization of DOC, pH increase, and input and SOM decomposition varying with rice growth [ 43 , 44 ].

Period effects for low-middle, middle, high-middle, and high SDI regions showed an improving trend before 2004, but an adverse trend after 2004.

Temporal trends in sex differences in suicidal ideation were observed in six countries, with five countries showing an adverse trend among girls compared to boys.

The analysis of probabilities revealed that resources exhibited greater uncertainty in ACE compared to GBE, but human health had an adverse trend for resources.

However, it also induced fluctuations in some metabolic and organ function indicators, as well as exerting an adverse trend on behavioral performance related to spatial learning and memory.