Endogenous Recovery of Fasting C-Peptide Decreases Progression of Sudomotor Small-Fibre Dysfunction in Adults With Diabetes: A Real-World Cohort Study.

Although the test for nonlinearity did not reach statistical significance ( p for nonlinearity = 0.086), the overall pattern is compatible with a threshold effect rather than a strictly linear dose–response relationship. 3.3 Threshold‐Based Classification of C‐Peptide Recovery and a Time‐Dependent Protective Effect Maximally selected rank statistics further characterised the threshold, identifying 126.8 pmol/L as the optimal ΔFCP cutoff in relation to the sudomotor small‐fibre outcome.

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