Barely Significant
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Outcomes of immune-checkpoint inhibitor rechallenge in metastatic clear-cell renal cell carcinoma: results from a global real-world evidence study.

ESMO Open · 2026 · PMC13123600 · PMID 42019087

1
hedged sentence
0.3120
closest p · 6.2× alpha
0.3120
boldest claim

The sentences

did not reach statistical significanceP = 0.312not close (p > 0.1)
Although median OS was numerically higher for patients rechallenged ≥12 months after prior ICI, this difference did not reach statistical significance (34.9 versus 25.9 months; P = 0.312, log-rank test) ( Figure 2 B).

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