Targeting CRTC2 reverses <i>STK11</i> mutant NSCLC tumor resistance to immunotherapy.

LKB1-KO tumors showed a significant gMDSC (granulocytic myeloid-derived suppressor cells) infiltration in comparison to controls, in addition to a decrease in the number of mMDSC (monocytic myeloid-derived suppressor cells), Treg and CD4 + T cells, and almost a complete loss of CD8 + T cells (both effector and memory, although the impact did not reach statistical significance) ( Fig. 1 E and SI Appendix, Fig.

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