FLNA (AUC = 0.5930, p = 0.114) and JAK1 (AUC = 0.6150, p = 0.051) exhibited modest discriminatory ability but failed to reach statistical significance: at a cut-off of 211.2, FLNA showed high sensitivity (92%) but low specificity (33%), whereas JAK1, at a threshold of 54.74, demonstrated relatively balanced sensitivity (84%) and specificity (44%) ( Figures 3B , E ).
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High-efficacy serum biomarkers PCSK9 and LCAT predict cognitive impairment in Parkinson's disease.
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