Cardiovascular risk in primary aldosteronism: inflammatory drivers, residual risk, and emerging combination strategies.

Biochemically, esaxerenone was associated with a mild increase in serum potassium (approximately 3.9 → 4.0 mmol/L) and a small decline in eGFR, neither of which necessitated dose adjustment or treatment discontinuation; urinary albumin-to-creatinine ratio (UACR) and BNP levels showed downward trends but did not reach statistical significance.

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