Multi-omics integration and Mendelian randomization reveal the mechanisms and experimental validation of curcumin targeting the RXRA-PI3K/AKT axis to enhance cisplatin sensitivity in gastric cancer.

Front Oncol · 2026 · PMC13124633 · PMID 42063729

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did not reach statistical significanceno p-value reported

In contrast, MR-Egger, simple mode, and weighted mode methods did not reach statistical significance, although their effect directions were generally consistent with the IVW estimate. 3.3.

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