Association and incremental predictive value of preoperative AISI and CALLY for postoperative pulmonary complications after McKeown esophagectomy following neoadjuvant chemoimmunotherapy.

Front Immunol · 2026 · PMC13124699 · PMID 42064083

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did not reach statistical significanceP = 0.161not close (p > 0.1)

DeLong testing showed that the combined model significantly outperformed AISI alone (P = 0.027), whereas the difference between the combined model and CALLY alone did not reach statistical significance (P = 0.161) For the biomarker-based models, the combined AISI-CALLY model showed a sensitivity of 0.707, specificity of 0.624, accuracy of 0.655, and a Youden index of 0.331, with an optimal cutoff value of 0.367.

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