Metabolic markers of kidney function and oxidative stress are associated with heart failure with preserved ejection fraction (HFpEF) in individuals with metabolic dysfunction-associated steatotic liver disease (MASLD).

Metabolomics · 2026 · PMC13124771 · PMID 42050051

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0.0100

closest p · 0.2× alpha

0.0100

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nominally significantp-value = 0.01actually significant

The only nominally significant interaction between MASLD and metabolite factors on HFpEF associations was for Factor 31, composed of the metabolites ketoglutarate and phenyl sulfate (p-value = 0.01).

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