PAI-1, MMP-9, and NLR combined with NIHSS for predicting 90-day poor functional outcome in elderly acute ischemic stroke: a prospective observational cohort study.

Front Neurol · 2026 · PMC13124988 · PMID 42064988

Europe PMC DOI

hedged sentences

0.0770

closest p · 1.5× alpha

0.0770

boldest claim

The sentences

did not reach statistical significancep = 0.077so close (0.05 < p ≤ 0.1)

In multivariable analysis, NIHSS score (OR, 2.24; 95% CI, 1.60–3.36; p < 0.001), MMP-9 (OR, 1.71; 95% CI, 1.32–2.35; p < 0.001), and NLR (OR, 1.42; 95% CI, 1.12–1.91; p = 0.011) were independently associated with poor outcome; PAI-1 showed a consistent effect direction but did not reach statistical significance ( p = 0.077).

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borderline significanceno p-value reported

This underscores that even markers with borderline significance can contribute meaningfully to multi-marker panels when supported by mechanistic rationale ( 21 ).

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