Integrated causal inference, kidney transcriptomics, and experimental validation identify ChREBP (<i>MLXIPL</i>) as a driver of maladaptive metabolic remodeling in diabetic kidney disease.

Front Endocrinol (Lausanne) · 2026 · PMC13125001 · PMID 42064763

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did not reach statistical significanceno p-value reported

Adipogenesis showed a similar directional trend but did not reach statistical significance ( Figure 6B ).

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Integrated causal inference, kidney transcriptomics, and experimental validation identify ChREBP (&lt;i&gt;MLXIPL&lt;/i&gt;) as a driver of maladaptive metabolic remodeling in diabetic kidney disease.

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Integrated causal inference, kidney transcriptomics, and experimental validation identify ChREBP (<i>MLXIPL</i>) as a driver of maladaptive metabolic remodeling in diabetic kidney disease.