TLR2 activation potentiates P-glycoprotein-mediated methotrexate efflux and enhances cytotoxicity of human NK cells against acute lymphoblastic leukemia.

While these increases did not reach statistical significance (p > 0.05), a consistent stepwise elevation in the median MFI values confirms that direct TLR2 ligation is sufficient to independently trigger a basal level of cytokine production.

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