Barely Significant
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An explainable machine learning model predicts pediatric varicella encephalitis.

Front Cell Infect Microbiol · 2026 · PMC13125112 · PMID 42064222

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Although the AUC showed only a modest increase from 0.977 to 0.987 (absolute increment 0.010), and the NRI of 0.0288 (95% CI: -0.0652 - 0.1229, P = 0.5478) did not reach statistical significance ( Figure 4B ), the introduction of laboratory indicators substantially improved the model’s goodness-of-fit and provided statistically significant incremental information.

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an increasing trendno p-value reported
Machine learning models development and performance evaluation In the training set, the AUC of each model exhibited an increasing trend with the expansion of the sample size, among which SVM, XGBoost, and Random Forest demonstrated stable performance, consistently maintaining high levels ( Supplementary Figure 1 ).

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