Short-Term Oral Spermidine Supplementation Modifies Aspects of Neurodegenerative Disease in Flies and Mice With MPS III.

J Inherit Metab Dis · 2026 · PMC13125739 · PMID 42050889

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failed to reach statistical significanceno p-value reported

unaffected controls (A), the levels failed to reach statistical significance.

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highly significantno p-value reported

Whilst differential expression of the metabolites spermidine and putrescine was not consistently observed in MPS IIIA or MPS IIIC flies c.f., control flies, we noted a highly significant reduction in the level of both polyamines with age in all animals (Figure 3C ).

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