Pretreatment with the psychedelic DOI mitigates LPS-induced hippocampal inflammation and behavioral impairments in mice.

Among anti-inflammatory cytokines, only IL-4 showed a nonsignificant trend toward elevation ( p = 0.06) at 24 h (Fig. 3 A), whereas IL-10 (Fig. 3 B) and IL-13 (Fig. 3 C), and IL-2 (Fig. 3 D) – a cytokine with dual pro- [ 57 ] and anti-inflammatory roles [ 58 , 59 ] – remained unchanged throughout the time course.

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Consistent with our findings in WT mice (see above), DOI alone (0.3 or 1 mg/kg) did not significantly alter basal cytokine levels in 5-HT 2A R-KO mice, except for a modest increase in IL-6 at 0.3 mg/kg that did not reach statistical significance (Fig. 1 C and Fig.

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