Identification of Alzheimer's disease subtypes and biomarkers from human multi-omics data using subspace merging algorithm.

Clinical consensus diagnosis of cognitive status (cogdx) is marginally significant ( p = 0.087), The clustering result suggests that the observed multi‐omics difference cannot be explained by age, sex, or APOE status (Table 2 ) and was only revealed by integrating the multi‐omics data‐driven approach. 3.1.2.

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Although the Braak stage did not reach statistical significance, Subtype 2 exhibited a visible enrichment of patients with higheest Braak scores, Braak score at VI, (20 of 36 in Cluster 2 vs 10 of 29 in Cluster 1).

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