Dynamic biomarker profiling and phenotyping in burn sepsis: a retrospective cohort study using growth mixture modeling.

Front Cell Infect Microbiol · 2026 · PMC13128616 · PMID 42079744

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hedged sentences

0.0030

closest p · 0.1× alpha

0.0970

boldest claim

The sentences

highly significantP = 0.003actually significant

4.3 Inflammatory dynamics IL−6 was significantly elevated in non−survivors throughout the 21−day period, and its trajectory exhibited a highly significant time−by−status interaction ( P = 0.003).

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showed a trendP = 0.097so close (0.05 < p ≤ 0.1)

In multivariable Cox analysis adjusting for age, NRS2002, Burn Index, and the five most significant biomarkers from univariable analysis (NK cells, TRF, CD4/CD8 ratio, NB, and PA), none of the biomarkers retained independent prognostic significance, although NK cells showed a trend toward protection (HR = 0.97, P = 0.097) ( Table 4 ).

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trend toward significanceP = 0.097so close (0.05 < p ≤ 0.1)

The strong protective association of NK cells in univariable analysis (HR = 0.95, P < 0.001) and its trend toward significance in multivariable modeling (HR = 0.97, P = 0.097) highlight the importance of innate immune competence.

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