Increased risk of cardiovascular diseases among patients with carpal tunnel syndrome in a multicenter global retrospective cohort study.

For relatively rare outcomes such as cardiac amyloidosis and carditis, point estimates remained elevated but did not reach statistical significance, likely reflecting reduced statistical power rather than attenuation of association.

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While the crude, unadjusted model showed a markedly higher risk (MACE HR 2.96), the association remained strong and highly significant after adjusting for demographics and medications (MACE HR 1.54) and further adjusting for major comorbidities (MACE HR 1.48) ( Table S6-S7 ).

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