Multi-ancestry genome-wide association study in all of Us for primary open-angle glaucoma.

For several additional loci, variants were either not present in the available summary statistics or did not reach statistical significance in the external datasets, although some demonstrated directionally consistent effects.

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The locus on chromosome 1 near TMCO1 demonstrated strong external support in the UK Biobank European ancestry dataset, where multiple variants within this region showed highly significant associations with POAG and consistent direction of effect.

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