Barely Significant
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Estrogen Deficiency in Menopause: A Major Contributor to Cartilage Degeneration and Osteoarthritis: A Systematic Review and Meta-Analysis.

J Menopausal Med · 2026 · PMC13129206 · PMID 42045087

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Human pooled estimates did not reach statistical significance, highlighting the need for larger, standardized studies.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.