The ERβ Agonist, OSU-ERβ-012, Mitigates Inflammation in a Chimeric Model of Systemic Lupus Erythematosus.

Quantification of these immune cell subsets revealed that the macrophages and T cells were significantly decreased in the hearts of both the mice treated with prednisone and OSU‐ERβ‐012 as compared to the mice treated with vehicle (Figure 2N and O ), whereas the neutrophils showed a decreased trend in the mice treated with OSU‐ERβ‐012 but did not reach statistical significance (data not shown).

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The increase in circulating IFNγ levels in the vehicle control was highly significant from baseline to three and five weeks, both of which were significantly suppressed by both OSU‐ERβ‐012 and prednisone (Supplementary Figure 4A ).

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