New sights of spleen-preserving versus splenectomy in distal pancreatectomy for pancreatic neuroendocrine tumors: a systematic review and meta-analysis.

Front Endocrinol (Lausanne) · 2026 · PMC13129563 · PMID 42077454

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did not reach statistical significanceno p-value reported

In Clement’s study ( 34 ), overall survival (OS) in the SPDP group did not reach statistical significance; however, the 5-year recurrence-free survival (RFS) was significantly shorter (not reached vs. 59 months; P = 0.028), which may be related to the potential immune preservation in the W-SPDP group.

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