FXII decline during cardiopulmonary bypass and the limits of routine coagulation assays: a prospective observational analysis.

Perioper Med (Lond) · 2026 · PMC13130502 · PMID 42057213

Europe PMC DOI

hedged sentences

0.0600

closest p · 1.2× alpha

0.0600

boldest claim

The sentences

did not reach statistical significancep = 0.06so close (0.05 < p ≤ 0.1)

For the entire study population, this relationship displayed the same trend but did not reach statistical significance ( ρ = − 0.427, p = 0.06).

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a nonsignificant trendno p-value reported

Other coagulation factors Factor V activity decreased significantly after CPB in all cohorts, while FVIII activity showed a nonsignificant trend toward higher values.

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