Dynamic changes in TREX1 and LGALS9 mRNA levels in PBMCs predict HBsAg clearance and treatment responses to Peg-IFN-α therapy in HBeAg-negative chronic hepatitis B patients.

Virol J · 2026 · PMC13130713 · PMID 41866580

Europe PMC DOI

hedged sentences

0.2542

closest p · 5.1× alpha

0.2542

boldest claim

The sentences

did not reach statistical significanceP = 0.2542not close (p > 0.1)

Although higher than the 0.8042 observed for HBsAg alone, this improvement did not reach statistical significance ( P = 0.2542).

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an increasing trendno p-value reported

Overall, TREX1 and LGALS9 mRNA levels exhibited an increasing trend during Peg-IFN-α therapy, with distinct patterns observed between response groups.

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