Circulating α-Klotho and Multidimensional Aging and Frailty Outcomes: A Systematic Review and Meta-Analysis from the European Renal Association CKD-MBD Working Group.

Calcif Tissue Int · 2026 · PMC13132909 · PMID 42060134

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did not reach statistical significanceno p-value reported

Using a random-effects model, the pooled analysis yielded a mean difference of − 18.07 ng/mL (95% CI: − 40.14, 4.00, p = 0.11), indicating that circulating α-Klotho levels were generally lower in individuals with cognitive impairment, though the result did not reach statistical significance.

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