Although not statistically significant, C12-494 LNPs formulated with cholesterol analogs showed a trend toward greater inhibition in the presence of methyl-β-cyclodextrin compared to the softer C12-494 Chol LNP, suggesting these LNP formulations may rely more on lipid-raft mediated endocytosis for uptake in ovarian cancer cells (Fig. 3 e).
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Examining the effect of lipid nanoparticle elasticity on endocytosis and mRNA delivery to cancer cells.
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