Preventing obesity-related cancer with the revolution in obesity management: the challenges of undertaking a clinical trial and potential solutions.

Br J Cancer · 2026 · PMC13133257 · PMID 41735582

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did not reach statistical significanceno p-value reported

However, in the LookAHEAD study, an RCT comparing intensive lifestyle intervention (ILI) compared to best medical advice suggested a possible preventative effect on obesity-related cancers after 11 years, but this did not reach statistical significance (RR = 0.84, 95% CI = 0.68–1.04) [ 13 ].

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