Single-cell and spatial profiling reveal cDC2A-CXCL13<sup>+</sup>CD8<sup>+</sup> T-epithelial cell crosstalk and cytotoxicity through TNFRSF9 in cutaneous and mucosal lichen planus.

Nat Commun · 2026 · PMC13133274 · PMID 41832141

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did not reach statistical significanceno p-value reported

While the increase in LAM cell infiltration in LPP compared with healthy scalps did not reach statistical significance (Supplementary Fig. 3C ), pathway enrichment analysis of upregulated genes in LAM cells revealed strong associations with the lysosome pathway and leukocyte transendothelial migration, particularly in LPP (Supplementary Fig. 3B ).

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Single-cell and spatial profiling reveal cDC2A-CXCL13&lt;sup&gt;+&lt;/sup&gt;CD8&lt;sup&gt;+&lt;/sup&gt; T-epithelial cell crosstalk and cytotoxicity through TNFRSF9 in cutaneous and mucosal lichen planus.

The sentences

Single-cell and spatial profiling reveal cDC2A-CXCL13<sup>+</sup>CD8<sup>+</sup> T-epithelial cell crosstalk and cytotoxicity through TNFRSF9 in cutaneous and mucosal lichen planus.