Complement factor H supplementation rather than complete C3 knockout provides therapeutic benefits in IgA nephropathy.

Mol Biomed · 2026 · PMC13133335 · PMID 42060028

Europe PMC DOI

hedged sentences

0.0760

closest p · 1.5× alpha

0.0760

boldest claim

The sentences

a decreasing trendp = 0.076so close (0.05 < p ≤ 0.1)

Notably, patients with higher circulating CFH levels also showed a decreasing trend in circulating IgA levels (3.13 ± 1.14 g/L vs. 3.36 ± 1.17 g/L, p = 0.076), although this difference was not statistically significant.

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showed a trendno p-value reported

Notably, C3 knock out showed a trend toward reduced urinary ACR in IgAN mice (Fig. 3 j), though this improvement was not statistically significant.

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